全文获取类型
收费全文 | 421篇 |
免费 | 38篇 |
国内免费 | 1篇 |
出版年
2023年 | 2篇 |
2021年 | 5篇 |
2020年 | 17篇 |
2019年 | 42篇 |
2018年 | 29篇 |
2017年 | 4篇 |
2016年 | 10篇 |
2015年 | 10篇 |
2014年 | 10篇 |
2013年 | 25篇 |
2012年 | 10篇 |
2010年 | 14篇 |
2009年 | 6篇 |
2008年 | 20篇 |
2007年 | 20篇 |
2006年 | 22篇 |
2005年 | 12篇 |
2004年 | 7篇 |
2003年 | 6篇 |
2002年 | 13篇 |
2001年 | 15篇 |
2000年 | 7篇 |
1999年 | 11篇 |
1998年 | 16篇 |
1997年 | 7篇 |
1996年 | 19篇 |
1995年 | 16篇 |
1994年 | 4篇 |
1993年 | 11篇 |
1992年 | 9篇 |
1991年 | 5篇 |
1990年 | 3篇 |
1989年 | 13篇 |
1988年 | 2篇 |
1987年 | 5篇 |
1986年 | 2篇 |
1985年 | 2篇 |
1984年 | 4篇 |
1983年 | 2篇 |
1982年 | 3篇 |
1981年 | 2篇 |
1980年 | 5篇 |
1979年 | 2篇 |
1978年 | 3篇 |
1977年 | 1篇 |
1976年 | 1篇 |
1974年 | 2篇 |
1972年 | 1篇 |
1967年 | 1篇 |
1937年 | 1篇 |
排序方式: 共有460条查询结果,搜索用时 15 毫秒
101.
102.
103.
The Stomach, Helicobacter pylori, and Acid Secretion 总被引:1,自引:0,他引:1
104.
Background
Doxazosin and its role as an antihypertensive agent have come under recent scrutiny as a result of the early termination of that treatment arm in ALLHAT. It is unclear why the cardiovascular (CV) event rate in this randomized, controlled trial (RCT), especially heart failure, is higher in those treated with a doxazosin-based regimen than with a chlorthalidone based-regimen. There has been little work in the past to summarize information on peripheral alpha-1 antagonists that may be helpful in evaluating the results of this randomized controlled trial. 相似文献105.
Weifeng Xu MS Xinwei Chen MD Yexin Wang MS Baoting Fan MS Ke Guo MS Chi Yang MD Shiqi Yu MD Yichuan Pang MD Shanyong Zhang MD 《Journal of cellular physiology》2020,235(3):3022-3032
Considering the high rate of osteoclast-related diseases worldwide, research targeting osteoclast formation/function is crucial. In vitro, we demonstrated that chitooligosaccharide (CS) dramatically inhibited osteoclastogenesis as well as osteoclast function dose-dependently. CS suppressed osteoclast-specific genes expression during osteoclastogenesis. Furthermore, we found that CS attenuated receptor activator of nuclear factor kappa B ligand (RANKL)-mediated mitogen-activated protein kinase (MAPK) pathway involving p38, erk1/2, and jnk, leading to the reduced expression of c-fos and nuclear factor of activated T cells c1 (NFATc1) during osteoclast differentiation. In vivo, we found CS protected rats from periodontitis-induced alveolar bone loss by micro-computerized tomography and histological analysis. Overall, CS inhibited RANKL-induced osteoclastogenesis and ligature-induced rat periodontitis model, probably by suppressing the MAPK/c-fos/NFATc1 signaling pathway. Therefore, CS may be a safe and promising treatment for osteoclast-related diseases. 相似文献
106.
107.
108.
Background
The western tarnished plant bug Lygus hesperus is an economically important pest that belongs to a complex of morphologically similar species that makes identification problematic. The present study provides evidence for the use of DNA barcodes from populations of L. hesperus from the western United States of America for accurate identification.Methodology/Principal Findings
This study reports DNA barcodes for 134 individuals of the western tarnished plant bug from alfalfa and strawberry agricultural fields in the western United States of America. Sequence divergence estimates of <3% reveal that morphologically variable individuals presumed to be L. hesperus were accurately identified. Paired estimates of Fst and subsequent estimates of gene flow show that geographically distinct populations of L. hesperus are genetically similar. Therefore, our results support and reinforce the relatively recent (<100 years) migration of the western tarnished plant bug into agricultural habitats across the western United States.Conclusions/Significance
This study reveals that despite wide host plant usage and phenotypically plastic morphological traits, the commonly recognized western tarnished plant bug belongs to a single species, Lygus hesperus. In addition, no significant genetic structure was found for the geographically diverse populations of western tarnished plant bug used in this study. 相似文献109.
R L Lavine D T Lowenthal M D Gellman S Kline L R Recant L I Rose 《European journal of applied physiology and occupational physiology》1980,43(1):41-44
Twelve highly conditioned long-distance runners were studied to determine the effects of marathon (42 km) and 10,000 m running on plasma immunoreactive glucagon (IRG), serum immunoreactive insulin (IRI), and serum glucose (G) levels. Blood samples were drawn just prior to and immediately upon completion of the run. Marathon running resulted in no significant change in G, IRI, or IRG levels. After running 10,000 m, plasma IRG levels did not change significantly, while IRI and G increased significantly. In evaluating the pooled data from both runs, a significant inverse correlation was observed between delta G and delta IRG. This relationship between delta G and delta IRG suggests that glucagon plays a role in maintaining normal blood glucose levels during strenuous exercise. 相似文献
110.
Akbar SM Sharma HC Jayalakshmi SK Sreeramulu K 《Journal of bioenergetics and biomembranes》2012,44(1):233-241
The cotton bollworm, Helicoverpa armigera is a polyphagous pest in Asia, Africa, and the Mediterranean Europe. Salicylic acid (SA) and jasmonic acid (JA) are the cell
signaling molecules produced in response to insect attack in plants. The effect of these signaling molecules was investigated
on the oxidative phosphorylation and oxidative stress of H. armigera. SA significantly inhibited the state III and state IV respiration, respiratory control index (RCI), respiratory complexes
I and II, induced mitochondrial swelling, and cytochrome c release in vitro. Under in vivo conditions, SA induced state IV
respiration as well as oxidative stress in time- and dose-dependent manner, and also inhibited the larval growth. In contrast,
JA did not affect the mitochondrial respiration and oxidative stress. SA affected the growth and development of H. armigera, in addition to its function as signaling molecules involved in both local defense reactions at feeding sites and the induction
of systemic acquired resistance in plants. 相似文献